MAGNESIUM CITRATE – HIGH BIOAVAILABILITY FOR BETTER THERAPEUTIC EFFECT

Organic magnesium citrate has a very good bioavailability as it is absorbed directly
in the small intestine.^1-2

• The absorption of inorganic magnesium salts such as magnesium oxide depends on the concentration of gastric acid. Magnesium oxide must therefore be taken about 30 minutes before a meal.
• Magnesium citrate can be taken anytime independent of meals.
• In a comparative study magnesium citrate, as compared to magnesium oxide, led to a significant higher increase in blood Mg concentration and showed therefore a better bioavailability.¹

• Magnesium citrate leads to a higher increase in the leukocyte magnesium level than magnesium oxide.4

•  Studies on bioavailability show that organic magnesium compounds are better absorbed.^1–4
• Magnesium citrate has the best bioavailability both after a single dose (24 h) and after 2 months of supplementation. ¹

NEUROMUSCULAR HYPEREXCITABILITY AND FIBROMYALGIA

A recent study shows that the administration of 300 mg of magnesium in the form of magnesium citrate to patients with fibromyalgia leads to a significant reduction in the degree of pain, limitations of life, depressive symptoms and tender points.

Magnesium citrate in the treatment of fibromyalgia⁵
Reduction of complaints in %

• Fibromyalgia (muscle fibre pain) is a chronic disease manifesting as general pain in the muscles and connective tissue and tenderness over certain points, so-called tender points.
• It is associated with numerous other physical and psychiatric signs and symptoms.
• Most patients with fibromyalgia suffer from chronic stress, lack of sleep, depression and other.

1. Walker et mg citrate found more bioavailable than other mg preparations in a randomised, double blind study. Magnesium Research 16 (2003) 183-191

2. Lindberg et al. Magnesium bioavailability from magnesium citrate and magnesium oxide. J Am Gol Nutr 9 (1990) 48-55a

3. Firoz, M. Graber. Bioavailability of US commercial magnesium preparations; Magnesium Research 2001 Dec; 14(4):257-62

4. A. Nestler et al. Magnesiumsupplementation erhöht intrazelluläre Mg2+ Konzentration in humanen Leukozyten. The FASEB Journal 2012;26:lb278

5. S. Bagis et al. ls magnesium citrate treatment effective on pain, clinical parameters und functional status in patients with fibromyalgia? Rheumatol lnt 2013 Jan; 33(1): 167-72