Reduced intake
- Low-caloric diet
- Unbalanced diet
- “Nutrient-depleted” food
Impaired absorption (malabsorption)
- Genetic defects
- Gastrointestinal diseases
- Medication (PPI)
Increased excretion
- Genetic defects
- Diseases (diabetes)
- Abuse of alcohol, laxatives
- Medication (diuretics, cyclosporine, cisplatin)
Loss of vitamins and minerals; example: refined wheat flour in % of whole-grain flour 1

The intensive exploitation of soils, the use of low-magnesium fertilizers, and the diet in industrialized countries resulted in a reduction of magnesium supply. 2
- G. Eby. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. Epub 2006 Mar 20
- Vormann et al. Dietary Magnesium Supply, Requirements and Recommendations – Results from Duplicate and Balance Studies in Man. Journal of Clinical and Basic Cardiology 2003; 5 (1), 549-53